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Hyaluronic Joint Complex Research
According to an article published in The Lancet, a British Medical Journal in 2001, Glucosamine slowed the progression of osteoarthritis.
In a three-year, double-blind, placebo controlled study of 212 participants, individuals given glucosamine showed improvement in pain and mobility, while those given a placebo worsened. Upon examination of X-rays, glucosamine showed a protective benefit preventing progressive damage to the knee joint.
Another three year, randomized, double blind, placebo-controlled study of 202 participants showed similar results according to a 2002 article published in the Archives of Internal Medicine.
A follow up analysis of the participants of these two studies performed five years later, suggested evidence that glucosamine reduced the need for knee replacement. This article was published in the July 26th, 2007 edition of Osteoarthritis Cartilage.
HYALURONIC ACID RESEARCH
Hyaluronic acid has been used for years by both human and veterinary medical doctors in injectable form to replenish the lubricating synovial fluid of the joints. It is used to treat osteoarthritis of the knee as well as various other joints of the body with significant success.
It has been shown that an oral supplement of Hyaluronic acid is readily absorbed through the intestines into the blood stream and distributed throughout the body in organs, bone and joints, according to a report presented by Dr. Alex Schauss, at the 2004 Experimental Biology Conference.
Hyaluronic acid helps cushion joints, reduce inflammation and carry nutrients to cartilage, in part, due to its excellent ability to retain water. Hyaluronic acid is available in injectable form under various names and is an FDA approved treatment for pain associated with osteoarthritis of the knee attesting to the numerous studies showing its efficacy.
In a study published in the February 8th, 2008 edition of Nutrition Journal,
researchers at Miami Research Associates showed that an oral dose of an 80 milligram supplement containing Hyaluronic acid showed greater benefit than a placebo for osteoarthritis of the knee.
CHONDROITIN RESEARCH
A large trial conducted by the National Institute of Health showed that the supplements glucosamine and chondroitin sulfate are more effective when taken together to reduce pain for the treatment of osteoarthritis of the knee.
Chondroitin is believed to enhance the shock absorbing properties of collagen and block enzymes that break down cartilage. According to Arthritis Today Magazine, a review of more than a dozen studies showed chondroitin significantly reduced pain and inflammation, and improved joint function, especially when combined with glucosamine.
Chondroitin is naturally occurring in human bone and cartilage. Most Chondroitin supplements come from bovine trachea or pork by-products, which might be objectionable if you are a vegetarian.
MSM RESEARCH
Methylsulfonyl-methane has been widely studied for multiple uses for its anti-inflammatory properties. MSM contains up to 34% sulfur by weight. It is widely believed that MSM may help deliver sulfur to the joints where it may be used by the body to strengthen the tissues of the joint. Sulfur helps maintain the structure of connective tissues of the joint.
As published in Osteoarthritis and Cartilage 2006, researchers at Southwest College of Naturopathic Medicine and Health Sciences, Tempe AZ, conducted a randomized double-blind, placebo controlled clinical trial showing 3000 milligrams twice daily showed significant reduction in pain for those suffering with osteoarthritis of the knee with no significant adverse side effects. An added benefit was a significant reduction in serum homocysteine levels, which is a marker for cardiovascular disease.
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